AP08956937 "Development of a method for preparation of biocompatible cryogels based on interpolyelectrolyte complexes"

Supervisor:

Relevance:

The project idea is to develop a new method for the synthesis of macroporous cryogels based on an interpolyelectrolyte reaction, which is carried out under conditions of shallow freezing of the reaction medium . Macroporous cryogels are promising materials for use in medicine, biotechnology, in catalysis, agriculture. However, the use of cryogels is significantly limited when synthetic polymersand harmful reagents are used in the synthesis of cryogels. The development of a new method for producing cryogels proposed in this project will solve this problem and produce a macroporous, biocompatible and biodegradable material with many useful properties.

Target:

The goal of the project is to develop a method for producing macroporous cryogels by conducting an interpolyelectrolyte reaction between oppositely charged polyelectrolytes (chitosan, gellan, sodium alginate and others) under moderate freezing of the reaction medium for the synthesis of macroporous biocompatible and biodegradable cryogels.

Expectation:

The main result of the project will be a new biocompatible material with wide application possibilities in biotechnology, medicine, water purification systems and other fields. The forms of implementation of the project result will be:
1) As a result of the project, 2 articles will be published, including 1 in a foreign scientific journal (for example, Polymer Bulletin, http://www.springerlink.com/content/102513 /), reviewed by the Web of Science database, having a quartile of at least Q2, a percentile of at least 58 and an impact factor of at least IF=1.71. As well as 1 article in the domestic magazine recommended by КОКСОН.
2) The field of application of the obtained cryogels is biotechnology, medicine, catalysis, ecology. The target consumers of the expected results are scientific and industrial organizations, as well as scientists engaged in developments in the field of biocompatible materials, as well as porous systems.
3) The impact of expected results on the development of the main scientific direction and related fields of science and technology. The results obtained will provide an opportunity for the development of polymer chemistry, medicine, biotechnology and ecology;
4) The expected results have a high potential for commercialization;
5) The social effect of the project is the opportunity to improve the qualifications of one of the team members, as well as to increase the competitiveness of Kazakhstani scientists through publications in international journals. The economic effect consists in the development of a new domestic technology for producing biocompatible materials, which eliminates the need to import similar materials from abroad. The ecological effect consists in the use of completely natural components in the synthesis of cryogels and their cleaning. The scientific and technical effect will be obtained through the development of a completely new technology for producing cryogels based on biopolymers. The multiplicative effect consists in the possible development of domestic endoprosthetics using completely domestic developments.

Result:

Published 1 article in a domestic journal Klivenko A.N., Mussabayeva B.Kh., Gaisina B.S., Sabitova A.N. Biocompatible cryogels: Preparation and application //Bulletin of the Karaganda University Chemistry Series. – 2021. – 3(103). – P. 4-20

Study Team Members

Fullname: Мусабаева Бинур Хабасовна

Scopus Id: 57191170085

Researcher Id: 000

ORCID: 0000-0003-2209-1209

Additionally:
Fullname: Елемесова Гульнур Тайбековна

Scopus Id: 000

Researcher Id: 000

ORCID: 0000-0002-1074-7111

Additionally: