AP09260805 "Development of a biosensor for the determination of highly cumulative xenobiotics in milk and dairy products based on regional monitoring of food safety"
Supervisor:
Relevance:
The development of agriculture in the Republic of Kazakhstan is inextricably linked with the technogenic impact, as a result of which numerous xenobiotics enter the human body along the trophic chain, among which there are contaminants with a pronounced carcinogenic effect. Identifying them in livestock products is time consuming and costly. The development of an express method for determining the residual amount of highly cumulative xenobiotics is very urgent, since it allows solving the main problems of ensuring the safety and quality control of milk and dairy products.
Target:
Study of the results of regional monitoring of food safety for the development of an accelerated method for determining the residual amount of xenobiotics in milk and dairy products.
Expectation:
- On the basis of regional monitoring of food safety in the intensively developed regions of the East Kazakhstan region, the most common and hazardous highly cumulative substances will be determined and their cumulation coefficient calculated. - A map of the EKR regions with a high content of dangerous xenobiotics in milk will be compiled.
- The direction of modernization of the accelerated method for the determination of xenobiotics in milk will be chosen.
- Design a biosensor model for the determination of highly cumulative xenobiotics in milk and dairy products
- Technical characteristics and instructions for the use of a biosensor for the determination of highly cumulative xenobiotics in milk and dairy products will be developed and approved.
- Normative and technical documentation will be developed and approved, a monograph will be issued and a patent received. Results will be published in cited journals.
Result:
Based on the analysis of information data, thexenobiotics in milk, as a raw material of animal origin, was substantiated, and regions of the East Kazakhstan were established to determine the residual amount of the most common and dangerous xenobiotics in milk. The most danxenobiotics in terms of the degree of cumulative properties have been established experimentally. A map of the regions of the East Kazakhstan with a high content of dangerous xenobiotics in milk has been compiled. The main directions of modernization of the biosensor for the determination of xenobiotics in milk and dairy products have been selected.
1. Study On the Detection of Antibiotics in Food Based on Enzyme - Free Labelless Aptamer Sensor. ZhainagulKakimova, Klara Zharykbasova, Aitbek Kakimov, Gulmira Mirasheva, Sandugash Toleubekova, Yerlan Zharykbasov, Gulnara Tulkebayeva, Alibek Muratbayev, AsiyaUtegenova. (Overview. At the stage of peer review). (Scopus Foreign publication);
2. Determination of xenobiotics in environmental objects. Gulnara Tulkebayeva, Nadir Ibragimov, Zhainagul Kakimova, Klara Zharykbasova, Gulmira Baybalinova. UDC 01.1 The IX International Science Conference «Trends of development modern science and practice», November 16 – 19, 2021, Stockholm, Sweden. 588 p. ISBN - 978-1-68564-518-2. DOI -10.46299/ISG.2021.II.IX. (Foreign publication).
Study Team Members
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Fullname: Какимова Ж.Х.
Scopus Id: 56955761100
Researcher Id: 2447-2021
ORCID: 0000-0002-3501-3042
Additionally:
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Fullname: Жарыкбасова К.С.
Scopus Id: 57191167555
Researcher Id: 000
ORCID: 0000-0002-2027-3183
Additionally:
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Fullname: Суйчинов А.К.
Scopus Id: 57197823757
Researcher Id: 000
ORCID: 0000-0003-4862-3293
Additionally:
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Fullname: Мирашева Г.О.
Scopus Id: 57189593618
Researcher Id: 000
ORCID: 0000-0003-4286-4563
Additionally:
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Fullname: Толеубекова С.С.
Scopus Id: 57189597951
Researcher Id: 000
ORCID: 0000-0003-2658-9514
Additionally:
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Fullname: Жарыкбасов Е.С.
Scopus Id: 57191171135
Researcher Id: 000
ORCID: 0000-0001-9707-0539
Additionally:
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Fullname: Ибрагимов Н.К.
Scopus Id: 57188718716
Researcher Id: 000
ORCID: 0000-0001-9607-8230
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Fullname: Тулькебаева Г.Е.
Scopus Id: 57226128014
Researcher Id: 000
ORCID: 0000-0002-1121-5520
Additionally:
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Fullname: Муратбаев А.М.
Scopus Id: 57206183950
Researcher Id: 000
ORCID: 0000-0002-0830-5007
Additionally:
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Fullname: Даулетярова Ж.А.
Scopus Id:
Researcher Id:
Additionally: